| abstract |
Betaadrenolytically effective substances consisting of 1-aryloxy-3-alkylamino-2-propanols of the general formula In wherein R¹ is alkyl with 3 to 4 carbon atoms, and R² is a ramified alkyl with 3 to 4 carbon atoms, such substances being prepared in a reaction in a polar solvent fromn (a) alkyl ester of 3-acetyl-4[(3-bromo-2-hydroxy)-propoxy]phenylcarbamic acid with a primary alkylamine; (b) alkyl ester of 3-acetyl-4[(2-3,epoxy)-propoxy]phenylcarbamic acid with a primary alkylamine in the medium of an alkanol with 1 to 3 carbon atoms; (c) alkyl ester of 3-acetyl-4-hydroxyphenylcarbamic acid with 1-alkylamino-2,3-epoxypropane, the reaction being catalyzed by an alkali metal hydroxide; and (d) alkyl ester of 3-acetyl-4-hydroxyphenylcarbamic acid with 1-alkylamino-3-chloro-2-propanol, the reaction being catalyzed by an alkali metal hydroxide. |