http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CS-260097-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8095fcbc14f32f140efa46074f127f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bf6e011c6a5445954e7766d5c2945559 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_99341dd4245140062abf6bca5f534629 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9605fba43df6fee201903430f71659b7 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D337-12 |
| filingDate | 1987-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24cbf3c3c43c605aefb800f141615d88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bca25fd4050cebea03ae356ad1ba9cbb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8aadcdb1c5fe16273eb49eeb67c3767 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c0cb9d6a80681360b6dfc831de45483 |
| publicationDate | 1988-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CS-260097-B1 |
| titleOfInvention | 11- (3-Dimethylaminopropyl) -6-11-dihydrodibenzo- / b.e / thiepine-2-carbonitrile and its maleate |
| abstract | The solution falls within the scope of synthetic drugs.nIts subject is antireserpine and anticholinergicneffective 11- (3-dimethylaminopropyl) -6,11-dihydrodibenzo [b, e] thiepine-n-2-carbonitrile and its maleate. In the formnof this salt except fornantireserpine and anticholinergicnhigh affinity for bindingnsites of [3 H] imipramine in the hypothalamus of ratsnat low binding affinity sitesn/ 3H / desipramine in the same brain structure.nThis suggests the possibility of reverse inhibitionn5-hydroxytryptamine intake in the brain and practicalnthe usefulness of the substance as an antidepressantnnew type. Preparation of the substance according to the solutionnconsists in the reaction of N, N-dimethyl-3- (2-bromo-n-6, ll-dihydro-dibenzo / b, e / thiepin-l l-yl) -npropylamine with copper (I) cyanide in hexamethylphosphoric triamidenat 150 ° C and chromatographicnseparation of the resulting mixture. neutralizationnbase with maleic acid is obtainedna crystalline maleate which is suitablenpharmacological tests as well as drug productionnforms |
| priorityDate | 1987-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.