http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CS-258497-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D457-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 |
| filingDate | 1987-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f85180101001463316342cf1b51693b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25701c0e7048b9a862193a4945c59f40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78c8f27aac87380d56eee099f7d86089 |
| publicationDate | 1988-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CS-258497-B2 |
| titleOfInvention | Process for the production of new 2-substituted ergoline derivatives |
| abstract | Process for preparing new 2-substitutednergoline derivatives of the formula I in whichnX represents an oxygen atom or sulfur atoms, R1 denotesnalkyl having 1 to 6 atomsncarbon, Y is C2H4, -CH = CH- orn-CBC-, R2 is optionally alkoxynC 1 -C 4 or nitrilena substituted phenyl group,nthiophenyl or pyridinylnand Et is ethyl andnmeans a single carbon-bondncarbon or carbon-carbon double bond, andnif Cg * - "'Customs is simplencarbon-carbon bond, then a hydrogen atom in positionn10 occupies the a-configuration as well as theirnpharmaceutically acceptable addition saltsnwith acids, where X isnoxygen atom, r! is methylnand - C 10 is a single bond,nthen Y-R2 is not -C2H4-phenyl orn-CssC-phenyl characterized in that it isnargolin derivatives of formula III, vnwherein Z is a halogen atom or a groupn-C “CH, acts in the presence of a catalystnand a base with a compound of the formula Hal-R 2 ornHC "C-R 2, wherein Hal represents a halogen atom, whereinnone reactant each represents a compoundncontaining halogen then optionallynthe CSC bond is hydrogenated or completely hydrogenatednthe urea derivatives are optionally convertednto thiourea derivatives and / or obtainednthe compounds are optionally converted by treatmentnacid to its physiologically compatiblenacid addition salts. Produced compoundsnare used as medicines. |
| priorityDate | 1985-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 101.