http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CS-258294-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b5baa2ef842bf27d92e8ec825818d51c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8095fcbc14f32f140efa46074f127f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_978ccf40444ebfc44eb9220436a527d1 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-12 |
| filingDate | 1987-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d194104df47030c5aa3874f35e54eac0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e994d4860ad676ecdd0c051abe160686 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ec87222c3849844318ae37fe2ffa6be |
| publicationDate | 1988-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CS-258294-B1 |
| titleOfInvention | Process for the preparation of pure 1- (tetrahydro-2-furyl) -3- (1-naphthyl) propane-2,2-dicarboxylic acid |
| abstract | The solution lies in the field of drug synthesis.nIts object is a clean preparation methodn1- (tetrahydro-2-furyl) -3- (1-naphthyl) -npropane-2,2-dicarboxylic acid (I), which is an intermediatenthe manufacture of medicaments, especially cerebral agentsnvasodilating activity. Waynpreparation of the substance according to this solution liesnin the hydrolysis of 1- (tetrahydro-2-furyl) -3- (1-naphthyl) propane-2,2-dicarboxylic acid diethyl esternaqueous alcoholic hydroxidenpotassium, followed by removal of ethanolndistillation, crystalline exclusionndipotassium salt of acid I by addition of a solutionnof potassium chloride, in Isolation of thisnsalt and its purification by recrystallization,nin the subsequent decomposition of the salt with an acidnhydrochloric acid, released in isolationnacid I by extraction with dichloromethane and crystallizationnfrom this solvent. Usage ^npure acid I as an intermediatendeletion of demanding distillations as a starting distillationnester, as well as other substances, from the acidnI prepared. |
| priorityDate | 1987-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.