http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CS-249534-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_272b9719727c5293d8a92daf67bc2859 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-22 |
| filingDate | 1985-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9be1665fc33525b0009ea299c0adf5f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19b0f30223c8832b9042bf86b02f7720 |
| publicationDate | 1987-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CS-249534-B2 |
| titleOfInvention | Method of cyclohexylurea's sulphonyled derivatives production |
| abstract | The present invention relates to a method of preparing N-{4-[2-(5-methyl-pyrazinyl-2-carboxamido)-ethyl)-benzenesulphonyl}-N'-cyclohexylurea or glipizide, which has the chemical structure (I),n by letting 4-[2-(5-methylpyrazinyl)-2-carboxamido)-ethyl]-benzenesulphonamide with the chemical structure (II), where R 1 = NH 2 , react with N-cyclohexyl trichloroacetamide with the chemical structure (III), where R 2 = NHCOCCl 3 , according to the following reaction scheme:n The reaction is carried out in the presence of a polar, aprotic solvent such as N-methylpyrrolidone (NMP), N,N-dimethylformamide (DMF), N,N-dimethylacetamide (DMA) or dimethylsulphoxide (DMSO) under anhydrous conditions in the presence of a base such as an alcoholate, amide or hydride of an alkali metal. The reaction mixture is heated under reflux condensation to 40-100°C and the reaction is going on for 2-5 hours. |
| priorityDate | 1984-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.