| abstract |
A quinolone inotropic agent of the formula:n or a pharmaceutically acceptable salt thereof, wherein «Het» is an optionally substituted 5- or 6-membered monocyclic aromatic heterocyclic group attached by a carbon atom to the 5-, 6-, 7- or 8- position of said quinolone; R, which is attached to the 5-, 6-, 7- or 8- position, is hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, C 1 -C 4 alkylsulphinyl, C 1 -C 4 alkylsulphonyl, halo, CF 3 , hydroxy, hydroxymethyl, or cyano; R 1 is hydrogen, cyano (C 1 -C 4 alkoxy)carbonyl, C 1 -C 4 alkyl, nitro, halo, -NR 3 R 4 or -CONR 3 R 4 where R 3 and R 4 are each independently H or C 1 -C 4 alkyl or together with the nitrogen atom to which they are attached form a saturated 5- or 6-membered heterocyclic group optionally containing a further heteroatom or group selected from 0, S and N-R 5 where R 5 is H or C 1 -C 4 alkyl; R 2 is H, C 1 -C 4 alkyl, or 2-hydroxyethyl; Y is H or C 1 -C 4 alkyl; and the dotted line between the 3- and 4- positions represents an optional bond. |