| abstract |
Process for preparing substituted amides of amyl chloride and tertiary amine,nlysergic acid and derivatives thereofnof formula (I)nR, -nR2-nr3-nR, -nis hydrogen, alkylnwith 1 to 4 carbon atoms and 1-hydroxy-n-2-alkyl having 2 to 4 atomsncarbon,nis hydrogen or alkyln1 to 2 carbon atomsnis an alkyl group having 1 to 4 atomsncarbon,nis hydrogen or alkylnwith 1 to 4 carbon atoms.nAccording to the invention, acid amides are producednlysergic and its substitution derivatives.nThey are physiologically active substances, in particularnS - (+) - 1-Butanol-z-amidenlysergic (methylergometrine) has a largentherapeutic significance.nAccording to the process of the invention these substances are presentnproduce lysergic acid condensationnor substitution derivatives thereof with an amine in the presence of phenyl-N-phenylphosphine |