| abstract |
Process for the production of (5Z, 13E) -propadiene derivativesnacids of formula I wherein R is hydrogen orntetrahydrofuryl- or tetrahydropyranol- or alpha-n-methoxybenzyl, A represents hydrogen when B is RO,nwherein R is as defined above, B is hydrogen,nwhen A is RO or A + B together is OCH 2 CH 2 OnR 1 represents n-butyl or phenoxy,noptionally substituted by general lactol reactionnof formula Π, wherein R, R 1, A and B are as defined abovenmeaning with the ylide of formula mn(C6H5> 3P = CHCH2CH2CH2COOK UH)nconsists in using an ylide of formula m, preparednin tetrahydrofuran by treatment with 0.02 to 0.2nexcess of the theoretical amount of tert-butanolnof potassium in tetrahydrofuran solution at temperaturen5 to 30 ° C, reacted in an inert atmospherenwith lactol of formula H in tetrahydrofurannat a molar ratio of 2 to 3: 1 at temperaturen-20 to +10 ° C for 0.2 to 2 hours, followed by stirringnthe reaction is terminated by sequential addition of saturated solutionnsodium chloride, water and after acidification with hydrogen sulfatenalkali metal to pH 2.1 to 2.5 is organicnthe layer separated and after extraction of the aqueous phase with tetrahydrofurannfrom the combined organic fractionsnafter evaporation of the solvent, the product is obtained in generalnof formula I.nThese substances are used in both human and veterinary applicationsnmedicine. |