http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CS-237711-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bf641a7774560f21f0622923bbcc186c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_db9595c960aa63eca13dbbbab70315e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5351c7c7495a9590a04172e9e70afbd1 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D475-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D475-08 |
| filingDate | 1983-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ab51218f706612a46f9b73d727558e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbbf2449fd9085589d61b73769102faf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bce04262e73d745b18851b66c690ecd |
| publicationDate | 1985-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CS-237711-B1 |
| titleOfInvention | Process for the preparation of 6,10-methenyl-5,6,7,8-tetrahedyric acid |
| abstract | The subject of the invention is a production methodn5,10-aetenyl-5,6,7,8-tetrahydrofolic acidnwhich is a precursor of leucovorin,nused as an antidotencytostatics of methotrexate or in the lure 'ndisorders of folic acid metabolism. Disadvantagesncurrent proceduresna process for the production of 5,10-methenyl-5,6,n7,8-tetrahydrofolic acid by reduction of the acidnfoliar hydrogen on the hydrogenation catalystnin aqueous medium and subsequentn5,6,7,8-tetrahydrofolic acid formlaclnformic acid, whereinnthe formylation is carried out in an inert atmosphere,neg under nitrogen, directly in the rection mixturenafter reduction while maintaining the resulting mixturenat 20 to 100 ° C for 0.1 ton8 hours and then 5,10-methenyl-n-5,6,7,8-tetrahydrofolic acid is isolated. |
| priorityDate | 1983-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.