http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CS-237484-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ef8f94985287772b47688232edbcadf http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_978ccf40444ebfc44eb9220436a527d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc9af3dcbd2e01ff554ca29ad0afd0da http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8095fcbc14f32f140efa46074f127f1 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 |
| filingDate | 1984-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_934e7f95e27f4906c20f9250c8a0d0c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_536347e3f9085484b10e8a6cfeed15a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cce9cbc842f585b9b5e150799e2217fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba1e03d32753ce5aa2f299cbe41a5f5a |
| publicationDate | 1985-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CS-237484-B1 |
| titleOfInvention | 11-piperazino-6,11-dihydrodibenzo (b, e) thiepines and their salts |
| abstract | The invention is within the scope of synthetic drugs.nIts subject matter is 11-piperazino-6,11-dihydrodibenzo (b, e) thiepinesnformula I,nwherein R represents a hydrogen atom or an atomnchlorine and R 1 is hydrogen, methyl ornethyl, and their salts with organic acids.nThe compounds of formula I and their salts exhibitnsignificant efficacy in antagonization assaysneffects of reserpine in mice and rats, which isntypical of potential antidepressants. Substancesnthus, the invention can be used in mental therapyndepression. The compounds of formula I are accessiblensubstitution reactions of the respectiven11-chloro-6,11-dihydrodibenzo (b, e) thiepinesnwith 1- (2-hydroxyethyl) piperazine, 1- (2-methoxyethyl) piperazinenand 1- (2-ethoxyethyl) -npiperazine under various conditions that arenpartially described in the examples. Neutralizationnof the base of formula I obtained with organic acids,npreferably oxalic acid ornmaleic acid are obtainedncrystalline salts which are suitable for implementationnpharmacological tests and preparationndosage forms. |
| priorityDate | 1984-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.