abstract |
The present invention relates to an enzyme production methodnand isolating 7-aminodesacetoxycephalosporanic acidnfrom desacetoxycephalosporinnusing specially developed, mobilizedncrosslinked cell catalystsnand permeabilized biomass, cellularnaggregates, or on the basis of each other. microbial cells containing themnpenicillin acylase enzyme.nThe obtained 7-aminodesacetoxycephalosporanic acidnserves as a basic intermediatenfor the production of semi-synthetic desacetoxycephalosporins,nespecially cefalexin. |