| abstract |
The subject of the invention is a production methodn4-amino-N1-methylpteroylglutamic acidnalso called methotrexate, whichnis now used as a classical cytostaticnto treat a number of malignant diseases.nDisadvantages of current procedures, ie.ntechnological and economic demandsnit removes the condensation processn2,4-diaaino-6-chloromethylpteridinenhydrochloride of the formula with N- (p-methylformylaminobenzoyl) glutamatenethylngiven formula in the presence of water atnpH 1 to 14. |