| abstract |
The invention relates to cephalosporin derivatives having a broad antibacterial spectrum andnthey exhibit antibacterial effect on various gram-negative and gram-positive bacteria.nMore specifically, the invention relates to 7- (β-substituted-benzoylureido) -phenylacetamide derivativesnthe cephalosporin of formula (I) where isnR1 is hydrogen or alkyl of 1 to 4 carbon atoms, xnR 8 is hydrogen or hydroxy,nR6 is hydroxy,nn number 2 or 3ntaking. at least two of R 1 are attached to adjacent carbon atoms, positionnR 1 is selected from positions 3 to 5 when R 1 is C 1 -C 4 alkyl,nand from positions 2-6 when R 1 is hydrogen, R 1 is hydrogen or methoxyl and R 8 is 5-memberedna heterocyclic ring including one or more nitrogen atoms and optionally a sulfur atom,nwhich is optionally substituted by C 1 -C 4 alkyl and pharmaceutically acceptablensuitable salts. |