http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CS-209853-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_794c0541eeb177127ba84aa959f0316a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P35-02 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-18 |
| filingDate | 1974-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6679a39a066770229b01ad7f9f6c2f6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3532fcddb2106fa67e8733a275c3bb55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fc5503ab27b71c3c404d41a2c7a6f7c |
| publicationDate | 1981-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CS-209853-B2 |
| titleOfInvention | Method of making the semisynthetic cephalosporine |
| abstract | 1480850 Enzymatic hydrolysis on synthesis of cephalosporins SNAMPROGETTI SpA 16 Dec 1974 [20 Dec 1973] 54336/74 Heading C2C Hydrolysis of a cephalosporin produced by increasing the size of the thia ring of penicillin G and/or the synthesis of a semi-synthetic cephalosporin from a 7-aminocephalosporanic acid whose thia ring has been produced by increasing the size of the thia ring of penicillin G, is effected by contacting the said cephalosporin or 7-aminocephalosporanic acid in a phosphate buffer at a pH at which said hydrolysis or synthesis takes place with bacterial cells of a strain of Escherichia coli or with penicillin acylase extracted from said cells and purified, a said synthesis being carried out in the presence of a molar excess of an acylating agent. Preferably cephalosporin G is hydrolysed to yield 7 - aminodesacetoxycephalosporanic acid. Alternatively a synthesis comprising reacting 7 - aminodesacetoxycephalosporanic acid or (7 - ADCA) 7 - aminocephalosporanic acid (7 - ACA) with a compound of the formula in which X<SP>1</SP> is H or a group inert during said synthesis, X<SP>11</SP> is an alkoxy or -NH 2 group and X<SP>111</SP> is H or a -NH 2 group, may be effected in the presence of the cells or enzyme and phosphate buffer. For example, 7-ADCA may be reacted with D(-)phenyl glycine methyl ester HCl(PGM) to obtain cephalexin, 7-ACA may be reacted with PGM to obtain cephaloglycine, or 7-ACA may be reacted with phydroxyphenylglycine ethyl ester to form 7#[21 - amino - 2 - (4 - hydroxyphenyl)acetamido] - 3 - hydroxymethyl(acetate)ceph- 3-em-4-carboxylic acid. |
| priorityDate | 1973-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.