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filingDate 1975-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_613083fe5ce3fd4e81f2cae49d475b7c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af0f0a4bcd0d22ebe579d1a7fef47234
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f718393c9a6ab2604fc5d5c1f84518a7
publicationDate 1981-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CS-207562-B2
titleOfInvention Method of making the derivatives of acids of 2,4,6-triiod-3/or 5/-/2,4,6-troiod-3/or 5/-aminobenzoyl/-aminoalcanoyl-amidobenzoo
abstract 1488903 X-ray contrast agent GUERBET SA 21 May 1975 [31 May 1974 31 July 1974] 24169/74 and 33900/74 Heading C2C [Also in Division A5] Novel compounds of Formula I wherein R 1 represents a hydrogen atom, a radical of the formula R 5 and R 6 being a hydrogen atom, a lower alkyl radical, a lower hydroxyalkyl radical or a lower alkanoyloxyalkyl radical, or a radical of the formula R 7 being a lower alkanoyl radical and R 8 being a hydrogen atom, a lower alkyl radical, a lower hydroxyalkyl radical or a lower alkanoyl radical, R 2 represents a hydrogen atom, a radical of the formula in which R 9 and R 10 have the meanings given for R 5 and R 6 , or a radical of the formula in which R 11 has the meaning given for R 7 or represents a hydrogen atom and R 12 has the meaning given for R 8 , R 3 represents a hydrogen atom, a radical of the formula in which R 13 and R 14 have the meanings given for R 5 and R 6 , or a radical of the formula in which R 15 has the meaning given for R 7 or represents a hydrogen atom or a polyhydroxy lower alkanoyl radical and R 16 has the meaning given for R 8 , R 4 represents a hydrogen atom, a lower alkyl radical or a lower hydroxyalkyl radical, a is 0 or 1, n is an integer from 1 to 5, m is 0 or 1, b is 1 or 2, the sum b + m being 2 or less, and the lower alkyl esters and their salts with pharmaceutically acceptable bases. (By lower alkyl and hydroxyalkyl radicals are meant radicals having 1-4 carbon atoms and by lower alkanoyl and hydroxy lower alkanoyl radicals are meant radials containing 2-6 carbon atoms) are prepared by reaction of a compound of Formula IV with a compound of Formula V Compounds of Formula IV above are prepared by reaction of an amine of Formula VI with an acid halide of Formula VII followed by hydrazinolysis. Compounds of Formula V above are prepared by one of the following methods (a) a compound of Formula VI above is reacted with a compound of Formula XIX (b) a compound of Formula XI is reacted with a compound of Formula XIX above; (c) a compound of Formula XII is reacted with a compound of Formula XIX above; (d) a compound of Formula XIV is reacted with a compound of Formula XIX above; or a compound of Formula III is reacted with a compound of Formula XX
priorityDate 1974-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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