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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70
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filingDate 1977-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da09e8b6a3fba50ccdf7e5ea85602dd2
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publicationDate 1980-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CS-199093-B1
titleOfInvention Antiviral agent
abstract Improved antiviral medicines are those which contain as active component (S)- or (RS)-9-(2,3-dihydroxypropyl)adenine of the formula I <IMAGE> where appropriate combined with 9-( beta -D-arabinofuranosyl)adenine of the formula II <IMAGE> The compounds are effective medicines for viral diseases such as, for example, vaccinia, herpes simplex 1, herpes simplex 2, measles, vesicular stomatitis and the like. The advantages of these medicines include low toxicity of (S)- and (RS)-9-(2,3-dihydroxypropyl)adenine, their easy availability and high stability. Combination with 9-( beta -D-arabinofuranosyl)adenine reveals the synergistic effect of the two components. This results in a lowering of the dosage of the toxic and costly 9-( beta -D-arabinofuranosyl)adenine, with the same biological action being achieved, and its breakdown in the body is restricted.
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