abstract |
The invention relates to PCSK9 inhibitors useful in the treatment of cholesterol lipid metabolism and other diseases in which PCSK9 intervenes, having the formula (I): or a salt, hydrate, solvate, prodrug, stereoisomer, N -oxide or pharmaceutically acceptable tautomer thereof, where R <sub> 1 </sub>, R <sub> 1 </sub>, R <sub> 1 </sub>, R <sub> 1 </ sub >, R <sub> 1 </sub>, R <sub> 1 </sub>, R <sub> 1 </sub>, R <sub> 1 </sub>, R <sub> 1 </ sub >, X <sub> 1 </sub>, X <sub> 2 </sub>, and X <sub> 3 </sub> are described herein |