http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CR-20190335-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9f572e7d4273008fb17b6cea1c70aac2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C68-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-724 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0012 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-724 |
| filingDate | 2019-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04721a81d914bd3fb7b1f18fdd3536e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02f61933285bd80380a1e5e22ba1e664 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f7a089216e195f7944125c05af8e20d |
| publicationDate | 2019-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CR-20190335-A |
| titleOfInvention | INDUSTRIAL PROCESS TO PREPARE 6-PERDESOXY-6-PER (2-CARBOXYETHYL) THIO-GAMMA-CYCLODEXTRIN (SUGAMMADEX SODIUM) SODIUM SALT |
| abstract | An industrial process for preparing the sodium salt of 6-perdeoxy-6-per (2-carboxyethyl) thio-gamma-cyclodextrin (Sugammadex sodium), comprising: a) reacting gamma-cyclodextrin with triphosgene in the presence of dimethylformamide (DMF) to obtain the intermediate compound 6-perdeoxy-6-perchloro-gamma-cyclodextrin; and b) reacting the intermediate compound 6-perdeoxy-6-perchloro-gamma-cyclodextrin with 3-mercaptopropionic acid in the presence of the sodium hydroxide base to obtain crude Sugammadex sodium. As an accessory, the crude intermediate 6-perdeoxy-6-perchloro-gamma-cyclodextrin obtained is purified. Additionally, the process comprises step c) of purifying the crude Sugammadex sodium by recrystallization to obtain pure Sugammadex sodium. The Sugammadex sodium obtained has a purity of the order of 96-98%. |
| priorityDate | 2018-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.