| abstract |
The present invention relates to ethynyl derivatives of the formula I in which: Y is N or C-Ry Res hydrogen, methyl halogen or nitrile: Res phenyl or pyridinyl, which are optionally substituted by halogen, lower alkyl or lower alkoxy: R / R independently regardless of whether they are hydrogen, lower alkyl or lower alkyl substituted by halogen, or Ry together with the N atom to which they are attached can form a morpholine ring, a piperidine ring or an azetidine ring, which are unsubstituted or substituted by one or more substituents chosen from lower alkoxy, halogen, hydroxy and methyl; R / R independently of each other are hydrogen or lower alkyl, or Ry R together form a cycloalkyl C, tetrahydrofuran or oxetane ring; or a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to the corresponding enantiomers and / or optical isomers and / or stereoisomers thereof. It has now been found surprisingly that the compounds os of the general formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor of subtype 5 (mGluR5). |