| abstract |
The present invention is directed to a pharmaceutical composition for oral administration, including methylnaltrexone, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable amphiphilic excipient, such as sodium dodecyl sulfate; methods for using them, for example, to reduce one or more side effects of opioid therapy such as opioid-induced constipation; and methods for its preparation. Additionally, the present invention provides a salt of formula (I) wherein A- is an anion of a pharmaceutically acceptable amphiphilic excipient, such as, for example, dodecyl sulfate; pharmaceutical compositions thereof; methods of use thereof; and methods for preparing them. |