| abstract |
The present invention relates to pharmaceutical compositions of 6- (6-hydroxy-methyl-pyrimidin-4-yloxy) -naphthalen-1-carboxylic acid (3-trifluoro-methyl-phenyl) -amide, to the use of the ( 6- (6-Hydroxy-methyl-pyrimidin-4- yloxy) -naphthalen-1-carboxylic acid trifluoro-methyl-phenyl) -amide, and to (3-trifluoro-methyl-phenyl) -amide compositions of 6- (6-Hydroxy-methyl-pyrimidin-4-yloxy) -naphthalen-1-carboxylic acid, in therapeutic applications, especially in indications with a deregulation / overexpression of vascular endothelial growth factor (VEGF), ( neo) -vascularization, and angiogenesis driven by vascular endothelial growth factor (VEGF), and to methods for making these compositions; The invention further relates to the specific forms of 6- (6-hydroxymethyl-pyrimidin-4-yloxy) -naphthalen-1-carboxylic acid (3-trifluoro-methyl-phenyl) -amide, and to the preparation and The use of these forms The present invention also relates to a new process for producing 6- (6-hydroxy-methyl-pyrimidin-4-yloxy) -naphthalen-1 (3-trifluoro-methyl-phenyl) -amide -carboxylic. |