| abstract |
A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 are independently hydrogen, deuterium, aryl, heteroaryl, C 1 -C 8 alkyl, and are optionally substituted with one or more substituents that are independently R 3, R 3 is an aryl, heteroaryl, one or more fluorine atoms, a C1-C6 alkyl containing one or more fluorine atoms, a C1-C6 alkyl containing one or more deuterium atoms, a C1-C6 alkyl containing hydroxy, the aryl being and the heteroaryl optionally substituted with one or more halogens, a fluorinated alkoxy, a fluorinated alkyl, a sulfonyl, one or more deuterium atoms, a C1-C6 alkyl, a C1-C6 alkoxy, a nitrile, or R3 is a C1- alkyl C6 optionally substituted with one or more of the following groups: COOR4, OCOR4, CONR5R6, NRSCOR6, OR4; where R4 is a C1-C10 alkyl optionally substituted with one or more fluorine atoms, deuterium, alkoxy, aryl carboxylate, carboxylate alkyl; R5 and R6 was selected nan independently from hydrogen, alkyl or can together form a 4-8 membered carbon ring; or R1 and R2 form a 3-10 membered carbon ring which optionally comprises O or N and is optionally substituted with a C1 alkyl or aryl -C10, heteroaryl optionally substituted with R3. |