abstract |
The present invention relates to compounds that respond to formula (I) in which: R represents a (C1-C6) alkyl, halo (C1-C6) alkyl group; R 'represents a group NR4R5, OR8; A and B, if present, independently represent one another, one or two carbon atoms, these carbon atoms being substituted with one or more hydrogens, (C1-C6) alkyl groups; the (C1-C6) alkyl group (s) being optionally substituted; A + B represent a maximum of two carbons; R1 represents a hydrogen atom or a (C1-C6) alkyl group; R2 and R3 independently represent each other, a hydrogen atom, a (C1-C6) alkyl group; the (C1-C6) alkyl group being optionally substituted; R4 and R5 independently represent each other, a hydrogen atom, a (C1-C6) alkyl group, or form, with the nitrogen atom to which they are attached, an azetidine, pyrrolidine, piperidine, azephan, piperazine heterocycle , homopiperazine, morpholine, thiomorpholine, thiomorpholine S-oxide, thiomorpholine S-dioxide, this heterocycle being optionally substituted with a (C1-C6) alkyl group, each representing R6 and R7 each a phenyl group, optionally substituted; Y represents a hydrogen atom, a halogen, a (C1-C6) alkyl, halo (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkoxy, (C1-C6) alkyl S (O) po cyano; R8 is a hydrogen atom, a (C1-C6) alkyl group, a halo (C1-C6) alkyl group, an allyl group, a (C1-C6) phenylalkyl group, the phenyl group being optionally substituted with 1 or 2 O groups -methyl; p represents an integer chosen from 0, 1 or 2; in the state of base or salt of addition to an acid or a base. Procedure of preparation and application in therapeutics. |