http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CO-6251250-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bde28565d28f037e78bf4a67776ee24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-472 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 |
| filingDate | 2009-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa47626412cecc21fc20041070eca77e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06cdc99167fa0bb191bd63dd5bf3fcf4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bab2e8473aa0e6ea3ccbcdea33831f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_253ed410e593d66558ee2be5cc42a5a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f47aa5644e0bbef016ea62866a714e14 |
| publicationDate | 2011-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CO-6251250-A2 |
| titleOfInvention | ISOQUINOLINONE DERIVATIVES AS AN NG3 ANTAGONISTS |
| abstract | Isoquinolone derivatives of the general formula are provided.The compounds are antagonists of NK3 and useful for the treatment of, e.g. psychosis and schizophrenia. 1.- A compound according to formula Ien where A represents N, CH or CR1; wherein each R 1 independently represents hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, -C (O) - C 1-6 alkyl, -C (O) -C 2-6 alkenyl, -C (O) -C2-6 alkynyl, -C (O) -O-C1-6 alkyl, -C (O) -O-C2-6 alkenyl, -C (O) -O-C2-6 alkynyl or phenyl, wherein said phenyl, C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl is optionally substituted with one or more substituents selected from halogen, hydroxyl, halo- C1-6 alkyl, nitro, C1-6 alkoxy, and NR2R3; wherein X represents hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 cyano alkynyl, -OR2, -OC (O) R2, -OC (O) NR2R3, -C (O) -NR2R3, -N ( R2) C (O) R3, -N (R2) -C (O) NR2R3 or NR2R3, or X represents a monocyclic, bicyclic or tricyclic part having 4 to 16 ring constituent atoms one of which is nitrogen, and where one, two or three ring constituent atoms, additionally, may be heteroatoms selected from N, O and S, and wherein said monocyclic, bicyclic or tricyclic part may be optionally substituted with one or more substituents W, wherein W is selected from hydrogen, hydroxy, halogen, cyano, (= O), -O- (CH2) cO-, where c is 2 or 3 (spiro), (CH2) d, where d is 5 or 6 (spiro), alkyl C1-6, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, -C (O) -C1-6 alkyl, -C (O) -C2-6 alkenyl, -C (O) -C2 alkynyl 6, -C (O) -O-C1-6 alkyl, -C- (O) -O-C2-6 alkenyl, -C (O) -O-C2-6 alkynyl, -OC (O) -C1 alkyl -6, -OC (O) -C2-6 alkenyl, ... |
| priorityDate | 2007-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.