| abstract |
The present invention relates to compounds, compositions, methods for the treatment of various neurological and psychological disorders, and to the use of the compounds in combination therapy. In particular, the present invention concerns such compounds, compositions and methods, where the compounds are novel derivatives of aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diacepins. 1.- A compound of formulas I (AD) having the following structure: where: X represents a 5 or 6-membered aromatic or non-aromatic monocyclic carbocycle or heterocycle selected from the group consisting of phenyl, pyridyl, 2-oxo- pyridin-1 (2H) -yl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, pyranyl, pyrrolyl, furanyl, thiophenyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazyllo, optionally 1-triazolyl, tetrazololide 4 times with radicals, as defined below, in R9, or other 5 or 6-membered aromatic or non-aromatic carbocycles or heterocycles, containing 1-4 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, optionally substituted 1 to 4 times with radicals, as defined below, in R9; or X is a carbocycle or heterocycle [5.5] -, [6.5] -, [6.6] -, or [6.7] -fused selected from the group consisting of indenyl, indanyl, benzofuranyl, benzothiophenyl, dihydrobenzothiophenyl , dihydrobenzofuranyl, indolyl, indolinyl, benzo [1,3] dioxolyl, benzooxazolyl, benzoisothiazolyl, benzoisoxazolyl, indazolyl, benzotriazolyl, naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, quinazolinyl, cinnolinyl, trinolazyl [1,2] benzo [1,2,4] triazinyl, 2,3-dihydro-benzo [1,4] dioxinyl, 4H-chromenyl, dihydrobenzocycloheptenyl, tetrahydrobenzocycloheptenyl, indolizinyl, quinolizinyl, 6aH-thieno [2,3-d] imidazolyl, 1H- pyrrolo [2,3-b] pyridinyl, imidazo [1,2-a] pyridinyl, pyrazolo [1,5- a] pyridinyl, [1,2,4] triazolo [4,3-a] pyridinyl, thieno [2 , 3-b] furanyl, thieno [2,3b] pyridinyl, thieno [3,2-b] pyridinyl, furo [2,3b] pyridinyl, furo [3,2-b] pyridinyl, thieno [3,2-d ] pyrimidinyl, furo [3,2d] pyrimidinyl, thieno [2,3-b] pyrazinyl, ... |