| abstract |
1. A compound of Formula I: or a pharmaceutically acceptable derivative thereof, wherein X is O, S, N-CN, N-OH, or N-OR10; W is N or C; the dotted line denotes the presence or absence of a link, and when the dotted line denotes the presence of a link or W is N, then R4 is absent, otherwise R4 is -H, -OH -OCF3, -halo, - (C1-C6) alkyl, -CH2OH, -CH2CI, -CH2Br, -CH2I, -CH2F, -CH (halo) 2, -CF3, -OR10, -SR10, -COOH, -COOR10, -C (O) R10 , -C (O) H, -OC (O) R10, -OC (O) NHR10, -NHC (O) R13, -CON (R13) 2, -S (O) 2R10, or-NO2; R10 is - (C1-C4) alkyl; each R13 is independently -H, - (C1-C4) alkyl, - (C1-C4) alkenyl, - (C1-C4) alkynyl, or -phenyl; Ar1 is Ar2 esc is the integer 0, 1, or 2; Y1, Y2, Y3 are independently C, N, or O; where no more than one of Y1, Y2, or Y3 can be O, and for each Y1, Y2, and Y3 that is N, the N is linked to a group R21, and for every Y1, Y2, and Y3 that is C , C is linked to two R20 groups, provided there is no more than a total of two (C1-C6) alkyl groups substituted on all Y1, Y2, and Y3; R12a and R12b are independently -H or - (C1-C6) alkyl; E is = O, = S, = CH (C1-C5) alkyl, = CH (C1-C5) alkenyl, -NH (C1-C6) alkyl, or = N-OR20; R1 is -H, -halo, - (C1-C4) alkyl, -NO2, -CN, -OH, -OCH3, -NH2, -C (halo) 3, -CH (halo) 2, -CH2 (halo), -OC (halo) 3, - OCH2 (halo); ... |