http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CO-6241137-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 |
| filingDate | 2009-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f53c91c8c2f747d74da70479773dee1d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf1dc3a8608dab0078c1553550572dd9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_391c4604da4f3577be62e0ef4ebf564e |
| publicationDate | 2011-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CO-6241137-A2 |
| titleOfInvention | CXCR4 CYCLE PEPTIDE ANTAGONISTS |
| abstract | 1.- A lactam-cycled peptide of formula I: R1-cycle [X1-Tyr-X3-DArg-2Nal-Gly-X7] -X8-X9 -characterized because: a) the lactam is formed by an amide bond between the side chain amino group of X1 and the side chain carboxyl group of X7, wherein X1 and X7 are, respectively, a pair selected from the group consisting of (D / L) Agl / Glu, Dab / Glu, and Dap / Glu, and R1 is Ac or n-hexanoyl; b) Lactam is formed by an amide bond between the side chain carboxyl group of X1 and the side chain group amino group of X7, wherein X1 and X7 are, respectively, a pair selected from the group consisting of Asp / ( D / L) Agl, Asp / Dab, Asp / Dap, Glu / (D / L) Agl, Glu / Dab, Glu / Dap, Glu / DDap, and Glu / Lys, and R1 is Ac or Bz, or where X1 and X7 are, respectively, a pair selected from the group consisting of succinyl / (D / L) Agl, succinyl / Dab, succinyl / DaP, succinyl / Lys, and succinyl / Orn, and R1 is absent; or c) lactam is formed by an amide bond between the a-amino group of X1 and the side chain carboxyl group of X7, wherein X1 and X7 are, respectively, a selected pair from the group consisting of Ala / Glu, Ala / DGlu, DAla / Glu, DAla / DGlu, Dap (Ac) / Glu, Gly / Asp, Gly / Glu, Gly / DGlu, Leu / Glu, Leu / DGlu, Lys / DGlu, Lys (Ac) / Glu, 2Nal / Glu, Phe / Glu, Phe / DGlu, DPhe / Glu, and DPhe / DGlu, and R1 is absent; od) Lactam is formed by an amide bond between a non-amino group, without side chain of X1 and the side chain carboxyl group of X7, where X1 and X7 are, respectively, a pair selected from the group consisting of ß -Ala / Asp, -Ala / Glu, 5-amino-valeryl / Asp, 5- aminovaleryl / Glu, 4-AMB / Glu, 4-AMPA / Asp, and 4-AMPA / Glu, and R1 is absent; or e) lantana is formed by an amide bond between the a-amino group of X2 and the side chain carboxyl group of X7, wherein X2 and X7 are, respectively, a pair selected from the group consisting of Tyr / Asp, Tyr / Glu, and Tyr / DGlu, and R1 and X1 are each absent; R1 is a substituent on the a-amino group of X1 when X1 contains an a-amino group and the a-amino group is not a constituent of the amide bond of lactam, selected from the group consisting of Ac, Bz, and n- hexanoyl, or is absent, wherein X1 is selected from the group consisting of (D / L) Agl, Asp, Dab, Dap, and Glu; X1 is selected from the group consisting of (D / L) Agl, Ala, - ß-Ala, DAla, 5-aminovaleryl, 4-AMB, ... |
| priorityDate | 2007-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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