| abstract |
or a pharmaceutically acceptable salt thereof, wherein: T, U and V are independently selected from CR3, CRA and N, such that (i) exactly one of T, U and V is CRA; and (ii) if X is CH2, Y is phenyl, and U and V are both substituted carbons, then T is not N; W is -C (= O) NR4-, -NR4C (= O) or NR4-NR4-C (= O) -; X is absent or is C1-C6 alkylene which is substituted with 0 to 4 substituents independently selected from: i) C1-C4 alkyl, (C1-C8 cycloalkyl) C0-C2 alkyl and C0-C2 phenylalkyl; ii) substituents which taken together to form a 3- to 7-membered cycloalkyl or heterocycloalkyl ring; and iii) substituents that are taken together with R4 to form a 4- to 7- membered heterocycloalkyl; and is C3-C16 cycloalkyl, 4- to 16-membered heterocycloalkyl, 6-to 16-membered aryl or 5-to 16-membered heteroaryl, each of which is substituted with 0 to 6 substituents independently selected from hydroxy, halogen, cyano, amino, nitro, oxo, aminocarbonyl, aminosulfonyl, COOH, C1-C6 alkyl, C2-C6 alkenyl, C2-C6a alkynyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 alkoxy alkyl, C 1 -C 6 haloalkoxy, C 2 -C 6 alkyl ether, C 1 -C 6 alkanoyl, C 1 -C 6 alkylsulfonyl, (C 3 -C 7 cycloalkyl) C 0 -C 4 alkyl, mono- or di- (C 1 -C 6 alkyl) amino, C 1 -C 6 alkanoylamino, mono- or di- (C1-C6 alkyl) aminocarbonyl, mono or di (C1-C6 alkyl) aminosulfonyl and (C1-C6 alkyl) sulfonylamino; Z1 and Z3 are independently N or CR2; Z2 is N, CR2 or CRA; Each R2 and each R3 is independently selected from hydrogen, halogen, cyano, amino, nitro, aminocarbonyl, aminosulfonyl, COOH, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkanoyl, C2-C6 alkyl ether, (C3-C7 cycloalkyl) C0-C4 alkyl, mono- or di- (C1-C6 alkyl) amino, C1-C6 alkylsulfonyl -C6, C1-C6 alkanoylamino, mono- or di- (C1-C6 alkyl) aminocarbonyl, mono- or di- (C1-C6 alkyl) aminosulfonyl and (C1-C6 alkyl) sulfonylamino; Each R4 is independently hydrogen, C1-C6 alkyl, (C3-C8 cycloalkyl) C0-C2 alkyl or ... |