| abstract |
1.- A CHARACTERIZED compound BECAUSE it responds to the Formula or a salt, prodrug or ester acceptable for pharmaceutical use thereof where: B is a ring selected from the group formed by Z is a bond, O, CH2, NH or S; X is N or CH; n1 is 0, 1, 2 or 3; n2 is 0 or 1; R1 is H, C1-7 alkyl, C3-7 cycloalkyl, optionally substituted heterocycle, optionally substituted phenyl, benzyloxy, or substituted benzyl; R2a and R2b are independently hydrogen or optionally substituted C1-3alkyl; W is hydrogen, OR3a, O (CO) R3a, O (CO) NR3aR3b, SR3a, NHR3a, NH (CO) R3a, CHR3aR3b, NH (CS) R3a, optionally substituted heterocycle, optionally substituted phenyl, R3a and R3b are independently hydrogen, C1-8 alkyl, C3-7 cycloalkyl, C4-10 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted C5-10 heteroaryl, optionally substituted C7-10 aralkyl, optionally substituted heteroaryl-C6-12 alkyl, optionally substituted heterocycle, optionally substituted phenyl, optionally substituted bicyclic ring system, or optionally substituted benzyl; m is 1 or 2; R4a and R4b are independently hydrogen, halogen, hydroxy, nitro, amino, cyano, C (O) R7, C (O) OR7, C (O) NR7R8, C (S) NR7R8, S (O) R7, S (O) 2R7, ... |