| abstract |
1. A compound having the structure according to formula (I): or a salt, isomer, prodrug, metabolite or polymorph thereof where the dotted lines between positions 2-3 and positions 3-9a in Formula (I) represents sites for each of the two double bonds present when X1R1 is present; the dotted lines between positions 3-3a and positions 9a-1 in formula (I) represent sites for each of the two double bonds present when X2R2 is present; the dotted line between position 9 and X4R4 in formula (I) represents the site for a double bond; X1 is absent or is lower alkylene; X2 is absent or is lower alkylene; wherein only one of X1R2 and X2R2 is present; X3 is absent, lower alkylene, lower alkylidene or -NH-; when the dotted line between position 9 and X4R4 is absent, X4 is absent or is lower alkylene; when the dotted line between position 9 and X4R4 is present, X4 is absent; X5 is absent or is lower alkylene; R1 is selected from hydrogen, alkyl (optionally substituted in one or more positions by halogen, hydroxy or lower alkoxy), lower alkyl sulfonyl, aryl, C3-C12 cycloalkyl or heterocyclyl, wherein aryl, C3-C12 cycloalkyl or heterocyclyl each is optionally substituted in one or more positions by halogen, aminosulfonyl, lower alkyl-aminosulfonyl, alkyl (optionally substituted in one or more positions by halogen, hydroxy or lower alkoxy) hydroxy or alkoxy (optionally substituted in one or more positions by halogen or hydroxy); R2 is selected from hydrogen, alkyl (optionally substituted in one or more positions by halogen, hydroxy or lower alkoxy), lower alkyl sulfonyl, aryl, C3-C12 cycloalkyl or heterocyclyl, wherein aryl, C3-C12 cycloalkyl or heterocyclyl each is optionally substituted in one or more positions by halogen, aminosulfonyl, lower alkyl-aminosulfonyl, alkyl (optionally substituted in one or more positions by halogen, hydroxy or lower alkoxy), hydroxy or alkoxy (optionally substituted in one or more positions by halogen or hydroxy); R3 is -C (O) -Z1 (R6), -SO2-NR7-Z2 (R8) or -C (O) -NR9-Z3 (R10); when the dotted line between position 9 and X4R4 is absent, ... |