http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CO-6190616-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a9e6421e9257148abad101e1ce6c162 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025 |
| filingDate | 2010-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9029a2c71412d37e29bb85beb27caf2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a029679e47d1a2d8fac73d1cdf6a5e9c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3debc3559f400bbb6eb88a54c6282533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7023f07b53830e2f4695286ea46ccdb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd5f96f358a27ce94de454e1b86d1752 |
| publicationDate | 2010-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CO-6190616-A2 |
| titleOfInvention | N-PHENYL-BIPIRROLIDINE SUBSTITUTED CARBOXAMIDS AND THERAPEUTIC USE |
| abstract | The present invention describes and claims a series of substituted N-phenyl-bipyrrolidine carboxarnides of formula (I), in which R, R1, R2, R3 and R4 are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and, therefore, are useful as pharmaceutical agents, especially in the treatment and / or prevention of a variety of diseases modulated by H3 receptors, including diseases associated with the central nervous system In addition, the present invention also describes methods for the preparation of substituted and intermediate N-phenyl-bipyrrolidine carboxamides therefor. 1. A compound of formula (I): in which R, R1, R2 and R3 are the same or different and independently of each other are selected from hydrogen, (C1-C4) alkyl or CF3; R4 is selected from the group that is dimethylaminomethyl, methanesulfonylmethyl, phenoxymethyl, vinylbenzene, ethynylbenzene, vinylpyridine, phenyl, benzofuranyl, dihydro-benzofuranyl, oxo-tetrahydro-benzofuranyl, benzodioxolyl, oxo-chromenyl, dihydrobenzo-dioxinyl, dioxo-tetrahydro-1H-benzo [e] diazepinyl, imidazopyridinyl , benzotriazolyl, benzoimidazolyl, oxo-dihydro-benzoimidazolyl, indolyl, indazolyl, naphthyridinyl, quinolinyl, benzoimidazothiazolyl, pyridinyl, pyrimidinyl, pyrrolyl, triazolyl, thienyl, thiazolyl, tetrahydrofuranyl or pyrrolidinyl; wherein said R4 is optionally substituted one or more times with a substituent selected from halogen, hydroxy, methyl, ethyl, isopropyl, propoxyethyl, phenyl, benzoyl, methoxy, difluoromethoxy, CF3, CN, acetyl, methanesulfonyl, sulfamoyl, dimethylamino, N-formyl -methylamino, 2-hydroxyethylamino, 2-methoxyethylamido, benzyloxymethyl, carboxyphenoxy, pyrazolyl, 3,5-dimethyl-pyrazolyl, imidazolyl, triazolyl, oxazolyl, pyridinyl, oxo-dihydro-pyridinyl, pyrimidinyl-methylamino, N-acetyl-piperine , morpholinylmethyl or 2-oxo-pyrrolidinyl; or its salt or its enantiomer or diastereomer. |
| priorityDate | 2007-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.