http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CO-6190528-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 |
| filingDate | 2009-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78d85dc50f085d3b2a4b25f8269b5627 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5eee4421e1bdc357adaf597c9e2c106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_399667f2290a9ddad869aa20cd33cd38 |
| publicationDate | 2010-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CO-6190528-A2 |
| titleOfInvention | AKT ACTIVITY INHIBITORS |
| abstract | 1. A compound according to Formula C: in which: a is 0 or 1; b is 0 or 1; m is 0, 1 or 2; p is 0, 1 or 2; R2 is independently selected from: (C1-C6) alkyl, (C1-C6) alkoxy; CO2H, halo, OH and NH2; The Y ring is cycloalkyl (C4-C7); R1 is selected from: H, oxo, (C = O) aObalkyl (C1-C10), (C = O) aOb-aryl, (C = O) aObalkenyl (C2-C10), (C = O) aOb alkynyl ( C2-C10), CO2H, halo, OH, Obperfluoroalkyl (C1-C6), (C = O) aNR7R8, CN, (C = O) aOb cycloalkyl (C3-C8), S (O) mNR7R8, SH, S ( O) m-(C1-C10) alkyl and (C = O) aOb-heterocyclyl, said alkyl, aryl, alkenyl, alkynyl, cycloalkyl, and heterocyclyl is optionally substituted with one or more substituents selected from R6; R6 is: (C = O) aOb C1-C10 alkyl, (C = O) aObaryl, C2-C10 alkenyl, C2-C10 alkynyl, (C = O) aOb heterocyclyl, CO2H, halo, CN, OH, Ob perfluoroalkyl C1 -C6, Oa (C = O) bNR7R8, oxo, CHO, (N = O) R7R8, S (O) mNR7R8, SH, S (O) m-C1-C10 alkyl or (C = O) aOb cycloalkyl C3-C8, said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R6a; R6a is selected from: (C = O) aOb (C1-C10) alkyl, Oa perfluoroalkyl (C1-C3), alkylene (C0-C6) -S (O) mRa, SH, oxo, OH, halo, CN, alkenyl (C2-C10), alkynyl (C2-C10), cycloalkyl (C3-C6), alkylene (C0-C6) -aryl, alkylene (C0-C6) -heterocyclyl, alkylene (C0-C6) -N (Rb) 2 , C (O) Ra, (C0-C6) alkylene -CO2Ra, C (O) H, and (C0-C6) -CO2H alkylene, said alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heterocyclyl is optionally substituted with up to three substituents selected from Rb, OH, (C1-C6) alkoxy, halogen, CO2H, CN, Oa (C = O) b (C1-C6) alkyl, oxo, and N (Rb) 2; R7 and R8 are independently selected from: H, (C = O) aOb (C1-C10) alkyl, (C = O) aOb cycloalkyl (C3-C8), (C = O) aOb-aryl, (CO) aOb- heterocyclyl, (C2-C10) alkenyl, (C2-C10) alkynyl, SH, SO2Ra, and (C = O) aNRb2, said alkyl, cycloalkyl, aryl, heterocyclyl, alkenyl, and alkynyl optionally substituted with one or more substituents selected between R6a, or R7 and R8 can be taken together with the nitrogen to which they are attached to form a monocyclic or bicyclic heterocycle with 3-7 members in each ring optionally containing, in addition to nitrogen, one or two additional heteroatoms selected from N, O and S, ... |
| priorityDate | 2006-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.