| abstract |
1. A compound of the formula 1: or a pharmaceutically acceptable salt thereof; where, regardless of each event, m is 0, 1, 2 or 3; n, o and p are independently of each event 1, 2, 3, 4 or 5; R1 is -OH, OC (O) R6, -OC (O) N (R6) (R7), or -N (R6) (R7); R2 is -OH, -N (R8) (R9), -N (R) C (O) N (R8) (R9), or -N (R) C (O) R10; or has the formula 1b; R3 is alkyl, halide, alkoxy, (cycloalkyl) alkoxy, arylalkyl, or -O (CH2) 2-N (R15) (R16); R4 is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, halide, nitro , amino, acyl, amido, acyloamino, aminoalkyl, acyloaminoalkyl, acyloaminoalkylamino, sulfonylaminoalkylamino, carboxylate, or -N = C (N (R) 2) 2; R5 is -OH or -N (R17) (R18); R6 and R7 are independent of each event H, alkyl, arylalkyl, heteroaryloalkyl, or - [C (R15) (R16)] n-R19; R8 and R9 are independent of each event H, alkyl, arylalkyl or heteroarylalkyl; R10 is alkyl, haloalkyl or - [C (R15) (R16)] or -COOR; R, R11, R12, R13, R14, R15, and R16, are independent of each H or alkyl event; R17 and R18 are independent of each event H, alkyl, arylalkyl, heteroarylalkyl, alkoxy or - [C (R19) (R20)} p-R21; R19 and R20 are independent of each event H, hydroxy, alkyl, alkoxy, amino, aminoalkyl, acyloamino, sulfonyloamino, aryl, arylalkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl; R21 is independent of each event H, alkyl, aryl, heteroaryl, heterocyclyl, heterocyclylalkyl, alkoxy, alkylsulfonyl, arylsulfonyl, alkylsulfonamide, arylsulfonamide, amino, amide or carboxyl; R22 independent of each event is halide or alkyl; R23 is selected from a group consisting of alkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl and haloalkyl; R24 is selected from a group consisting of alkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl and haloalkyl; and R25 is selected from a group consisting of alkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl and haloalkyl. |