| abstract |
1. An amide compound of the d-amino -? - hydroxy -? - aryl alkanoic acid of the Formula (I): wherein: R1 is hydrogen, halogen, optionally halogenated alkyl, cycloalkyl, hydroxyl, optionally halogenated alkoxy, cycloalkoxy, lower alkoxy-lower alkoxy, or carboxy-lower alkoxy or lower alkyl free or esterified or amidated; R2 is hydrogen, halogen, optionally halogenated lower alkyl, hydroxy, cycloalkyl, cycloalkoxy, lower alkoxy-optionally halogenated lower alkyl, alkoxy optionally substituted lower-lower alkyl, cycloalkoxy-lower alkyl; hydroxy-lower alkoxy optionally lower alkoxylated, halogenated, or suffocated; lower amino-alkyl which is unsubstituted or substituted by lower alkyl, by lower alkanoyl, and / or by lower alkoxy-carbonyl, optionally hydrogenated heteroaryl-lower alkyl, lower amino-alkoxy which is substituted by lower alkyl, by lower alkanoyl, and / or by lower alkoxycarbonyl; Lower oxoalkoxy, lower alkoxy, lower alkenyloxy, cycloalkoxy-lower alkoxy, lower alkoxy-lower alkoxy, lower alkoxy-lower alkenyl, lower alkenyloxy-lower alkoxy, lower alkoxy-lower alkenyloxy, lower alkenyloxy-lower alkyl, lower alkoxy-lower alkoxy lower thioalkyl-optionally lower S-oxidized lower alkoxy, lower thioalkyl- (hydroxy)-lower alkoxy, aryl-lower alkoxy, aryl-lower alkyl, aryl-lower alkoxy, optionally hydrogenated heteroaryl-lower alkoxy, optionally hydrogenated heteroaryl-lower alkyl, cyano - lower alkoxy, cyano-lower alkyl, free or esterified or amidated lower carboxy-alkoxy, or free or esterified or amidated lower carboxy-alkyl; or R2 is in the meta position and is lower alkoxy-lower alkoxy optionally substituted by halogen (s); R3 is halogen or trifluoro-methyl; R4 is hydrogen, halogen, optionally halogenated lower alkyl, hydroxyl, lower alkoxy or optionally halogenated cycloalkoxy, lower alkoxy-lower alkyl, cycloalkoxy-lower alkyl, hydroxy-lower alkyl, thioalkyl-lower optionally S-oxidized lower alkyl, heterothioaryl-optionally hydrogenated lower alkyl, ... |