abstract |
1.- Compounds of formula and enantiomers and pharmaceutically acceptable salts and esters thereof, where X1 is O, S, CH2 R1 is hydrogen or C1-7-alkyl; R2 is hydrogen or C1-7-alkyl, or, if X1 is CH2, R2 is hydrogen, C1-7-alkyl or C1-7-alkoxy; R3 is hydrogen or C1-7-alkyl; R4 and R8 independently of each other are hydrogen, C1-7-alkyl, C3-7- cycloalkyl, halogen, C1-7-alkoxy-C1-7-alkyl, C2-7-alkenyl, C2-7-alkynyl, fluoro-C1-7 -alkyl, or cyano-C1-7-alkyl or cyano; R5, R6 and R7 independently of each other are hydrogen, C1-7-alkyl, C3-7 -cycloalkyl, halogen, C1-7-C1-7-alkoxy-alkyl, C2-7-alkenyl, C2-7-alkynyl, fluoro- C1-7-alkyl, - cyano-C1-7-alkyl or cyano; and one of R5, R6 and R7, is, where X2 is S, O, NR9, (CH2) pNR9CO, or (CH2) pCONR9, R9 is hydrogen , C1-7-alkyl, C3-7-cycloalkyl, fluoro-C1-7-alkyl, hydroxy-C2-7-alkyl, or C1-7-alkoxy-C2-7-alkyl; Y1, Y2, Y3 and Y4 are N or C-R12, and 1 or 2 of Y1, Y2, Y3 and Y4 are N and the others are C-R1 2; R10 is C1-7-alkyl, C3-7-cycloalkyl, fluoro-C1-7-alkyl, or C1-7-alkoxy-C1-7-alkyl; R11 is hydrogen, C1-7-alkyl, C1-7 -alkoxy-C1-7-alkyl; R12 independently of each other in each case is selected from hydrogen, C1-7-alkyl, C3-7-cycloalkyl, fluoro-C1-7-alkyl, C1-7-alkoxy-C1 -7-alkyl, hydroxy-C1-7-alkyl, C1-7-alkylthio-C1-7-alkyl, carboxy -C1-7-alkoxy -C1-7-alkyl, carboxy, carboxy-C1-7-alkyl, mono - or di-C1-7-alkyl-amino-C1-7-alkyl, C1-7-alkanoyl-C1-7-alkyl, C2-7-alkenyl, and C2-7-alkynyl; ... |