| abstract |
1.- Microbiological process for preparing 7a-substituted 11a-hydroxysteroid of the general formula 4, B where R7 is the PQ group, where P is a C1-C4 alkylene and Q is a hydrogen, C1-C4 alkyl or fluoralkyl-C1 -C4 and the PQ group is linked through P to the basic steroid structure, R10 may be in position a or β and be H, CH3 or CF3, and R13 is methyl or ethyl, where a 7a-substituted steroid of the general formula 3, A: where R7, R10 and R13 have the same meaning as indicated above, it is hydroxylated and oxidized using a microorganism, selected from the group comprising Aspergillus sp. , Beauveria sp., Glomerella sp., Gnomonia sp., Haplosporella sp. and Rhizopus sp.2.- Method according to claim 1, characterized in that the microorganism is selected from the group comprising Aspergillus awamori, Aspergillus fischeri, Aspergillus malignus, Aspergillus niger, Beauveria hassiana, Glomerella cingulata, Gnomonia cingulata, Haplosporella hesperedol and Rhizopusolonifer. |