| abstract |
1.- Compounds of the formula generally where R1 is one of the following groups R2 is lower alkyl, lower alkynyl, - (CH2) nO-lower alkyl, - (CH2) nS-lower alkyl, - (CH2) n-CN, - (CR´R ") nCF3, - (CR´R") nCHF2, - (CR´R ") n-CH2F, - (CH2) n- C (O) O-lower alkyl, - (CH2) n- halogen, or is - (CH2) n-cycloalkyl, optionally substituted by one or more substituents chosen from the group consisting of phenyl, halogen and CF3; R ', R "independently of n and independently of each other are hydrogen, lower alkyl, lower alkoxy, halogen or hydroxy; R3, R4 independently of one another are hydrogen, lower alkyl, lower alkoxy, phenyl or halogen; R5 is hydrogen, lower alkyl, - (CH2) n-CF3 or - (CH2) n-cycloalkyl; R6 is hydrogen or halogen; R7 is hydrogen or lower alkyl; R8 is hydrogen, lower alkyl, lower alkynyl, - (CH2) n-CF3, - (CH2) ncycloalkyl or - (CH2) n-phenyl, optionally substituted by halogen ; R9 is hydrogen, lower alkyl, -C (O) H, -C (O)-lower alkyl, -C (0) -CF3, -C (0) CH2F, -C (0) -CHF2, -C (O) -cycloalkyl, -C (0) - (CH2) nO - lower alkyl, -C (O) 0 (CH2) n-cycloalkyl, -C (O) -phenyl, optionally substituted by one or more substituents chosen from the group consisting of halogen and -C (O) O-lower alkyl, or is -S (0) 2-lower alkyl, -S (0) 2-CF3, - (CH2) n-cycloalkyl or is - (CH2) n-phenyl, optionally substituted by halogen; n is 0, 1, 2 , 3 or 4; and pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof |