| abstract |
1. A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein R 1 is H, halogen, NO 2, alkyl, carboxaldehyde, hydroxyalkyl, dihydroxyalkyl, arylalkoxy, arylalkyl, alkenyl, alkynyl, arylalkyl, -CN, aryl , alkanoyl, alkoxy, alkoxyalkyl, haloalkyl, haloalkoxy, carboxyl or arylalkanoyl, in which the aryl portion of the arylalkoxy, arylalkyl and arylalkanoyl is not substituted or is substituted with 1, 2, 3, 4 or 5 groups that are independently halogen, alkyl C1-C4, nitro, CN, haloalkyl, haloalkoxy or CO2R; wherein the alkyl portion of the alkyl, hydroxyalkyl, dihydroxyalkyl, arylalkoxy, arylalkyl, alkanoyl, alkoxy, alkoxyalkyl and arylalkanoyl groups is unsubstituted or substituted with 1, 2 or 3 groups that are independently halogen, C1-C4 alkoxy, alkoxy C1-C4 carbonyl or C3-C7 cycloalkyl; R2 is H, OH, halogen, -OSO2-alkyl (C1-C6), OSO2-aryl, arylalkoxy, aryloxy, arylthio, arylthioalkoxy, arylalkyl, alkoxy, aryloxyalkyl (C1-C6) , alkyl, alkynyl, -OC (O) NH (CH2) naryl, -OC (O) N (alkyl) (CH2) naryl, alkoxyalkoxy, dialkylamino, alkyl, alkoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, alkoxyalkoxy, NR8R9, dialkylamino or CO2R, in which n is 0, 1, 2, 3, 4, 5 or 6; whose groups are not substituted or substituted with 1, 2, 3, 4 or 5 groups which are independently halogen, -C1-C6 alkyl-N (R) CO2R30, haloalkyl, heteroaryl, heteroarylalkyl, -NR6R7, R6R7N- (C1-C6 alkyl) -, -C (O) NR6 R7, -C1-C4 alkyl-C (O) NR6R7, - (C1-C4 alkyl) -NRC (O) NR16R17, haloalkoxy, alkyl, CN, hydroxyalkyl, dihydroxyalkyl, alkoxy, alkoxycarbonyl, phenyl, -SO2-phenyl wherein the phenyl and -SO2-phenyl groups are optionally substituted with 1, 2 or 3 groups that are independently halogen or NO2 or -OC (O) NR6R7, wherein R16 and R17 are independently H or C1-C6 alkyl; or R16, R17 and the nitrogen to which they are attached form a morpholinyl ring; ... |