| abstract |
1. A compound of formula (I) or (II) in which A is nitrogen and B is carbon, or A is carbon and B is nitrogen; R0 is an aryl optionally substituted with one or more substituents, or a heteroaryl optionally substituted with one or more substituents R1 is aryl optionally substituted with one or more substituents, heteroaryl optionally substituted with one or more substituents, -CH = CH-R1a, or -CH2CH2-R1a, wherein R1a is hydrogen or a chemical moiety selected from (C1-C8) alkyl, partially or fully saturated carbocyclic ring (s) of 3 to 8 members, partially or fully saturated heterocycle 3 to 8 members, aryl, heteroaryl, in which the chemical moiety is optionally substituted with one or more substituents. X is a bond or -C (R2a) (R2b), wherein R2a and R2b are each independently hydrogen, (C1-C4) alkyl, or (C1-C4) alkyl, substituted with halo; R3a and R3b are each independently hydrogen, (C1-C4) alkyl, or (C1-C4) alkyl substituted with halo; and R4 is a chemical moiety selected from the group consisting of (C1-C8) alkyl, aryl, heteroaryl, aryl (C1-C4) alkyl, partially or fully saturated carbocyclic ring (s) of 3 to 8 members, heteroarylalkyl (C1-C3), lactone of 5 to 6 members, lactam of 5 to 6 members, and a partially or fully saturated heterocycle of 3 to 8 members, wherein said chemical moiety is optionally substituted with one or more substituents; a pharmaceutically acceptable salt thereof, a prodrug of said compound or said salt, or a solvate or hydrate of said compound, said salt or said prodrug. |