| abstract |
1. A compound of Formula I: or a pharmaceutically acceptable solvate, hydrate or salt thereof, wherein: Z is -S (O) - or -S (O2) -; R1 is C1-4 alkyl, halo, amino, C1-6 alkylthio, C2-6 alkenylthio, C1-6 alkoxy, trifluoromethyl, methylsulfonyl, or benzylthio; Ar is phenyl, naphthyl, pyridyl, imidazolyl, thiazolyl, furanyl, thienyl, benzothiazolyl, pyrazolyl, pyrimidinyl, benzimidazolyl, benzofuranyl, indolyl, benzothiophenyl or benzo [c] chromenyl, any of which is optionally substituted; R2, R3 and R4 independently hydrogen, C1-4 alkyl, C6-10 aryl, C1-4 hydroxyalkyl, C1-4 aminoalkyl, C1-4 monoalkylamino, C2-6 alkyl, C1-4 dialkylamino (C2-6) alkyl, carboxyalkyl (C1-4), cyano, nitro, amino, C1-4 alkoxy, hydroxy, or -CO2RW, where RW is hydrogen, hydroxy, C1-4 alkoxy, cyano, C1-4 alkoxycarbonyl, C1-4 alkyl, C3 cycloalkyl 8, phenyl, benzyl, wherein Rd and Re are independently hydrogen, C1-6 alkyl, C2-6 alkenyl or phenyl, Rf is hydrogen, C1-6 alkyl, C2-6 alkenyl or phenyl, and Rg is hydrogen, C1 alkyl -6, C2-6 alkenyl or phenyl, and Rh is ar C6-10 (C1-4) alkyl or C1-6 alkyl; and R7 is hydrogen, chlorine, fluoro or amino.2.- A compound of claim 1, wherein R1 is halo, C1-4 alkylthio or C2-4 alkenylthio. |