| abstract |
1. A compound of formula (I) or a pharmaceutically acceptable salt thereof: in which: X is halogen, cyano, nitro, S (O) nR6 or C1-4 alkyl, which is substituted by one or more halogen atoms ; Y is selected from hydrogen, halogen, CN, nitro, SO2R3, OR4, SR4, SOR3, SO2NR4R5, CONR4R5, NR4R5, NR6SO2R3, NR6CO2R6, NR6COR3, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6-alkyl, C1-6 alkyl the last four groups optionally substituted by one or more substituents independently selected from halogen, OR6 and NR6R7, S (O) nR6, where n is 0, 1 or 2; Z is aryl or a ring A, where A is a ring six-membered heterocyclic aromatic containing one or more nitrogen atoms, or it may be a fused 6.6 or 6.5 bicycles containing one or more O, N, S atoms, all aryl or A rings being optionally substituted by one or more substituents independently selected from hydrogen, halogen, CN, OH, SH, nitro, COR9, CO2R6, SO2R9, OR9 , SR9, SOR9, SO2NR10R11, CONR10R11, NR10R11, NHSO2R9, NR9SO2R9, NR6CO2R6, NHCOR9, NR9COR9, NR6CONR4R5, NR6SO2NR4R5, aryl, heteroaryl, alkenyl C2-C6-C6, C6-C6 alkyl, C6-C6 alkyl groups optionally substituted by one or more substituents independently selected from halogen, C3-C7 cycloalkyl, OR6, NR6R7, S (O) nR6 (where n is 0, 1 or 2), CONR6R7, NR6COR7, SO2NR6R7 and NR6SO2R7.R1 and R2 independently represent a hydrogen atom, halogen, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl or a C1-6 alkyl group, the last four groups being optionally substituted by one or more substituents independently selected from halogen, C3-C7 cycloalkyl, NR6R7, OR6, S (O) nR6 (where n is 0, 1 or 2); or R1 and R2 together can form a 3-8 membered ring that optionally contains one or more atoms selected from O, S, NR6 and in turn optionally substituted by one or more C1-C3 alkyl or halogen; ... |