| abstract |
1.- Compounds of formula (I) where R1 is-lower alkyl, -CH2-aryl, -cycloalkyl, - (CH2) 3 -OC (= O) CH3, -alcohol lower, -alkyl-R10, -CH2COOH, or -CH2CH2OCH2CH3; R2 is-lower alkyl, -CH2-aryl, -alcohol lower, -CH2C (= O) NH2, or -alkyl-R10, where at least one of R1 or R2 is -CH3; R3 is -COOH , -alkyl-lower-COOH, -alcohol lower, -CH2OCH3, -CH2NH2, -CH2NHSO2R11, -C (= O) R12, -CNHCH2CH2-R12, -C (= NH) -R12, - (CH2) nNHC (= O ) R13, - (CH2) mC (= O) N (R15) (R16), - C (= NH) -R17, or - (CH2) n-R18; R4 is -H, -alkoxide lower, -OC ( R7R8) C (= O) R19, -halogen, -SCH3, -C = CHC (= O) -R10, -CH2CH2C (= O) -R10, -O-lower alcohol, -OCH2CH (OH) CH2N = N ± N¯, -OCH2CH2OCH2CH2Cl, -NHC (= O) CH2-R10, -NHC (= O) CH2-lower alkyl, -O (CH2) n-cycloalkyl, -O-lower alkene, or a 5-membered unsaturated heterocyclic ring containing a heteroatom that is S or O; R5 and R6 are each independently -H, -halogen or-lower alkoxide; R7 and R8 are each independently -H or -CH3, R10 is an h 5 or 6-membered saturated heterocyclyl containing 1 or 2 heteroatoms, where each heteroatom is selected from N and O and the group binds the rest of the molecule to an N in the ring; R11 is -CF3, -alkyl lower, -CH2Cl , -CH2CF3, or -R12; R12 is a saturated or substituted or unsubstituted saturated 5- or 6-membered heterocyclic ring containing a heteroatom selected from N, O and S where the substituted ring is the heterocyclic ring substituted with -OH or - phenyl; R13 is - lower alkyl, - lower alkoxide, or - (CH2) nR14; R14 is a saturated or unsaturated 5 or 6 membered heterocyclic ring containing one or two heteroatoms that are selected from N and O; R15 is -H or -CH3; R16 is -H, -alkyl lower, -C = N, -OH, -alkoxide lower, or -CH2COOCH2CH3; ... |