| abstract |
1. A compound of formula I or a pharmaceutically acceptable salt thereof, in which: A is a structure i, ii or iiiC is aryl or heteroaryl, wherein each of the aryl and heteroaryl groups is optionally substituted with 1 - 3 of R2; B is selected from cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, aryl, substituted aryl, het and substituted het, or B and one of R2, if present, together with the phenyl carbon atoms to which B and R2 are joined, form het, where het is optionally a substituted het, with the proviso that when C is phenyl optionally substituted with R2, B is not where Q is independently selected from H, C1-C6 alkyl , -O-C1-C6 alkyl, phenyl, benzyl, -OH, CF3, CCl3, -NR3R3, -C1-C6-NR3R3 alkylene, C1-C6- (CH2-phenyl) NR3R3 alkylene, C1-C6-alkylene- (CH2 -benzyl) -NR3R3, and R1 is selected from H, -OH, alkyl, cycloalkyl, alkoxy, alkenyl, amino, substituted alkyl, alco xi substituted and substituted alkenyl; Each R2 is independently selected from H, alkyl, amino, NO2, -CN, halo and substituted alkyl; and Each R3 is independently selected from H or C1-C6 alkyl. |