| abstract |
1. A compound of formula (I): in which R1 is hydroxy or NHSO2R1A wherein R1A is (C1-8) alkyl, (C3-7) cycloalkyl or ((C1-6) alkyl (C3-7) alkyl )), which are all optionally substituted 1 to 3 times with halo, cyano, nitro, O (C1-6) alkyl, amido, amino or phenyl, or R1A is C6 or C10 aryl which is optionally substituted from 1 to 3 times with halo, cyano, nitro, (C 1-6) alkyl, O (C 1-6) alkyl, amido, amino or phenyl; R2 is cycloalkyl (C4-6); R3 is t-butyl or cycloalkyl (C5-6) and R4 is cycloalkyl (C4-6), or a pharmaceutically acceptable salt thereof.2.- The compound of formula I according to claim 1, wherein R1 is hydroxy, NHSO2Me, NHSO2-cyclopropyl or NHSO2-Ph .3.- The compound of formula I according to claim 2, wherein R1 is NHSO2-cyclopropyl or NHSO2-Ph.4.- The compound of formula I according to claim 2, in wherein R1 is hydroxy. 5. The compound of formula I according to any one of claims 1 to 4, wherein R2 is cyclopentyl or cyclohexyl. 6. The compound of formula I according to claim 5, wherein R2 It is cyclopentyl. |