| abstract |
1. A method for treating or preventing diseases or conditions mediated through the action of oxytocin, which comprises administering to an mammal in need thereof an effective amount of a compound of the formula (I) and / or a derivative physiologically acceptable thereof, wherein: R 1 represents (C 1-4) arylalkyl or a 5-7 membered cycloalkyl group optionally substituted with one or more hydroxyl groups, which is fused to an optionally substituted benzene ring; R2 represents C1-6 alkyl (optionally substituted by a C1-2 alkoxy group, C1-2 alkyl, di (C1-2 alkyl) amino or a C3-6 cycloalkyl) or C3-6 cycloalkyl, or a 5-6 membered heterocyclic group containing a single heteroatom selected from O, S or N, a nitrogen atom which carries a hydrogen atom or a methyl or ethyl group; R3 represents optionally substituted phenyl, a 5- or 6-membered heteroaryl group or a fused bicyclic ring system, which contains 9-10 ring members, which may be a carbocyclic group or this may contain up to 3 heteroatoms selected from O, S or N, and one of the fused rings is benzene; R4 represents OH or O-C1-4alkyl (optionally substituted with C1-4alkylcarbonyloxy) or NR5R6; R5 represents hydrogen, C1-6 alkyl (optionally substituted with C1-4 alkoxy) or C3-7 cycloalkyl; R 6 represents hydrogen, methyl, C 1-4 alkoxy, C 3-7 cycloalkyl, C 1-4 alkyl [optionally substituted with one or more groups selected from carboxyl, C 1-4 alkylsulfonyl or C 1-4 alkoxycarbonyl], C2-4 [optionally substituted with one or more groups selected from halogen, hydroxy, C1-4 alkoxy or NR7R8 wherein R7 and R8 independently represent hydrogen or C1-4 alkyl, or together with the nitrogen atom to which are joined to form a 3-7 membered saturated heterocyclic ring, which may contain an additional heteroatom selected from O, S or N (and heterocyclic group which may be substituted by 1 to 3 groups selected from C1-3 alkyl, hydroxy, C1-3 alkoxy (optionally substituted by C3-6 cycloalkyl or optionally substituted phenyl), C3-6 cycloalkyl or NRcRd, wherein Rc and Rd, each independently, represents a group selected from C1 alkyl -3 (optionally substituted by c C3-6 icloalkyl or optionally substituted phenyl) or C3-6 cycloalkyl)], ... |