| abstract |
1. A compound of formula (I): in which: R1 represents a group selected from: each of which optionally contains another heteroatom N, Z represents an optional halogen substituent, -CH2NH2, -NRaRb or -CN, ZAND # 39 represents an optional halogen substituent, -CH2NH2 or CN, alk represents alkylene or alkenylene, T represents S, O or NH; R2 represents hydrogen, - (C1-3 alkyl) CONRaRb, - (C1-3 alkyl) CO2 (alkyl C1-4), - (C1-3 alkyl) morpholino, -CO2 (C1-4 alkyl) or - (C1-3 alkyl) CO2H; X represents phenyl, or a 5- or 6-membered aromatic or non-aromatic heterocyclic group which It contains at least one heteroatom selected from O, N or S, each of which is optionally substituted with 0-2 groups selected from halogen, -CN, -C1-4alkyl, -C2-4alkenyl, -CF3, -NRaRb , NO2, -N (C1-4 alkyl) (CHO), -NHCO (C1-4 alkyl), -NHSO2Rc, (C0-4 alkyl) ORd, -C (O) Rc, -C (O) NRaRb, - S (O) nRc and -S (O) NRaRb; Y represents (i) a substituent selected from hydrogen, hal Gene, -CN, -C1-4alkyl, -C2-4alkenyl, -CF3, -NRaRb, NO2, -N (C1-4alkyl) (CHO), -NHCO (C1-4alkyl), -NHSO2Rc, ( C0-4 alkyl) ORd, -C (O) Rc, -C (O) NRaRb, -S (O) nRc or -S (O) 2RaRb, or (ii) phenyl, or an aromatic or non-aromatic heterocyclic group of 5 or 6 members containing at least one heteroatom selected from O, N or S, each of which is optionally substituted with 0-2 groups selected from halogen, -CN, -C1-4 alkyl, -CF3, - (CH2 ) nNRaRb, (CH2) nN + RaRbCH2CONH2, (C0-4 alkyl) ORd, -C (O) Rc, -C (O) NRaRb, S (O) nRc, -S (O) 2NRaRb, = O, oxide a an N, -CHO, -NO2 and -N (Ra) ring (SO2Rc); ... |