| abstract |
1. A compound represented by Formula (I): wherein R1 is, in each position, independently represented by hydrogen, optionally substituted by alkyl, optionally substituted by cycloalkyl, methoxy, thiomethoxy, -NHA, -NA2, -NHC ( = O) A, aminocarbonyl, -C (= O) NHA, -C (O) NA2, halogen, hydroxy, -OA, cyano or aryl; A is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl or optionally substituted alkynyl; R2 is represented by (i), (ii), (iii) or (iv) following: R3 is -H, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted C3-6 cycloalkyl, or AOH; N is 2, 3 or 4; P is a heterocyclic ring; R4 is -H or optionally substituted C1-4 alkyl; R5 is = O , = NR4 or = S; R6 is -H or methyl; Y is -C (= O) NH, -C (= O) NA-, -C (= O) N (A) -, -NHC (= O ) -, -C (= S) NH-, -CH2NH-, -C (= O) CH2-, -CH2C (= O) -, -C (= O) -piperazine-, -C (= O) R8 , -NAC (= O) -, -C (= S) N (A) -, -CH2N (A) -, -N (A) CH2- or a 5-membered heterocyclic. R7 is a monocyclic or bicyclic aromatic ring or a heterocycle, optionally substituted by one or more substituents selected from R8-R9 and R10; where R7 is connected to Y, either by a single link or by a ring fusion; R8 is -CH2, -C (= O) -, -SO2, -SO2NH-, -C (= O) NH-, -O-, -S-, -S (= O) -, a five-membered heterocyclic connected to R7 by a ring fusion or a single bond as ligation; R9 is morpholine optionally substituted with at least one substituent selected from A, thiomorpholine, piperazin-R11, optionally substituted aryl, ... |