| abstract |
1. A compound comprising an isomeric mixture of a modified cyclosporine analogue in the 1-amino acid residue with a 1,3-diene substituent, in which the range of the isomeric mixture by the substituent diene corresponds between about 10 % to about 90% of the E isomer and about 90% to about 10% of the Z isomer. 2. The compound of Claim 1, wherein the non-deuterated isomers constitute the E and Z isomers, as Specify below: 3. The compound of Claim 1 or 2, wherein the isomeric mixture comprises about 15% to about 85% of the E isomer and about 85% to about 15% of the Z.4 isomer. The compound of Claim 1 or 2, wherein the isomeric mixture comprises about 25% to about 75% of the E isomer and about 75% to about 25% of the Z.5 isomer. Claim 1 or 2, wherein the isomeric mixture comprises about 35% to about 65% of the E isomer and about 65% to about 35% of the Z isomer. |