| abstract |
1. A compound having the general formula I: where R 1 represents one or more substituents selected from hydrogen and halogen atoms and hydroxy, alkyl, haloalkyl, alkoxy, haloalkoxy, nitro, phenyl, substituted phenyl, heterocycle, substituted heterocycle and NR3R4, where each of R3 and R4 independently represents a hydrogen atom or an alkyl, acyl or alkoxycarbonyl group; R2 represents one or two substituents selected from hydrogen atoms and alkyl groups; Y represents a CH2 group or a bond; Q represents a carbonyl, thiocarbonyl or sulfonyl group; A represents an alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, heterocycle, alkylamino, dialkylamino, arylamino or aralkylamino group, each of which is optionally substituted; n is 1 or 2; X represents a selected amino portion of y -N (R5) -CH2-, where R5 represents a hydrogen atom or a methyl or benzyl group and W represents a bond, a nitrogen atom or a group CH, CH2, C (CN ) C (OH) or C (COCH3) (when W represents a nitrogen atom or a group CH, C (CN) C (OH) or C (COCH3), group ZB joins the atom W of the ring); when X represents a group Z represents a bond, an oxygen or sulfur atom or a group CH2, CH2CH2, CO, CHOH, OCH2, NH, NHCO or NHCONHCH2, when X represents a group -N (R5) -CH2-, Z represents a CH2CH2 or CH2O group, or Z and B together represent a 2,3-dihydrobenzo [1,4] dioxin-2-yl group; and except as stated above, B represents a monocyclic or bicyclic aryl group or a monocyclic or bicyclic heterocycle, each of which is optionally substituted; or an enantiomer, diastereomer, N-oxide, crystalline form, hydrate, solvate or pharmaceutically acceptable salt of this compound. 2. A compound according to claim 1, wherein R1 represents a hydrogen atom. |