| abstract |
1. A compound of the Formula (I) racemic-diastereomeric mixtures, optical isomers, pharmaceutically acceptable salts, prodrugs or biologically active metabolites thereof, wherein: G is where Z100 is or a group optionally substituted with R1 selected from the group consisting of alkyl, cycloalkyl, pyrrolidinyl, quinolinyl, quinoxalinyl, quinazolinyl, isoquinolinyl, phthalazinyl, imidazo [1,2-a] pyrimidinyl; 1H-imidazo [1,2-a] imidazolyl; imidazo [2,1-b] [1,3] thiazolyl, naphthyl, tetrahydronaphthyl, benzothienyl, furanyl, thienyl, benzoxazolyl, benzoisoxazolyl, benzothiazolyl; thiazolyl, benzofuranyl, 2,3-dihydrobenzofuranyl, indolyl, isoxazolyl, tetrahydropyranyl, tetrahydrofuranyl, piperidinyl, pyrazolyl, pyrrolyl, pyrrolopyridinyl, H-pyridinone, oxazolyl, isothiazolyl, oxadiazolyl, thiadiazolyl, 1,2-imidazolyl [indiazolyl] pyridinyl, benzoisothiazolyl; 1,1-dioxibenzoisothiazolyl, pyrido-oxazolyl, pyrido-thiazolyl, pyrimido-oxazolyl, pyrimido-thiazolyl and benzimidazolyl; Z110 is a covalent bond, or an optionally substituted (C1-C6), which is optionally substituted with one or more substituents selected from the group consisting of alkyl, CN, OH, halogen, NO2, COOH, substituted or unsubstituted amino and substituted or unsubstituted phenyl; Z111 is a covalent bond, an optionally substituted (C1-C6) or an optionally n-substituted (CH2) n-cycloalkyl- (CH2); ... |